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23 July 2003

Finding patterns of non-continuous characters with a given gap region from DNA sequences
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Speaker: ZHANG Minghua

Abstract

The development of bioinformatics provides us with a lot of data, such as DNA sequences. Nowadays people are trying to discovery useful information from the huge amounts of data. As we know, DNA sequences are of double-helix structure. For a nucleotides in a DNA sequence, after a helix turn, there exists another nucleotide shares a similar orientation as the previous one. The distance between the two nucleotides is a variable whose domain is normally a small region. When a molecule binds to a DNA sequence, it may take direct contacts with the nucleotides of the same orientation simultaneously. Therefore, the patterns composed of these nucleotides that appear frequent enough may contain valuable information for biologist.

In this talk, we formally define the problem we mention above, and present several straightforward algorithms for solving it. We point out the disadvantages of the algorithms, and present ideas of how to overcome the shortcomings.

Read the Presentation Slides...

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